SGMS1(SMS1);

Phosphatidylcholine:ceramide cholinephosphotransferase 1;

Sphingomyelin synthase 1;

Pig (Sus scrofa). 

N/A

Bidirectional lipid cholinephosphotransferase capable of converting phosphatidylcholine (PC) and ceramide to sphingomyelin (SM) and diacylglycerol (DAG) and vice versa. Direction is dependent on the relative concentrations of DAG and ceramide as phosphocholine acceptors. Directly and specifically recognizes the choline head group on the substrate. Also requires two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Does not function strictly as a SM synthase. Suppresses BAX-mediated apoptosis and also prevents cell death in response to stimuli such as hydrogen peroxide, osmotic stress, elevated temperature and exogenously supplied sphingolipids. May protect against cell death by reversing the stress-inducible increase in levels of proapoptotic ceramide. Required for cell growth.

Golgi apparatus membrane Multi-pass membrane protein

418

N/A

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A0AAS4

PF14360

ssc:100037303

PF01569

Ssc.14400

A0AAS4

9823.ENSSSCP00000011122